Gene information
Official symbol AGT
Official full name angiotensinogen
Gene type protein-coding gene
Chromosome1q42.2
Previous symbolSERPINA8
Gene familySerpin peptidase inhibitors; Neuropeptides
Resources
Entrez Gene 183
HGNC HGNC:333
Ensembl ENSG00000135744
Vega OTTHUMG00000037757
UCSC uc001hty.6
GO terms: 129 records
GO Description Category LogP Number of genes Detail
GO:0001655 urogenital system development GO Biological Processes -19.5104956 58 More
GO:0001822 kidney development GO Biological Processes -16.2664835 49 More
GO:0002027 regulation of heart rate GO Biological Processes -9.97103962 23 More
GO:0003012 muscle system process GO Biological Processes -27.3938503 63 More
GO:0003013 circulatory system process GO Biological Processes -65.2875605 130 More
GO:0003014 renal system process GO Biological Processes -10.4348518 24 More
GO:0003018 vascular process in circulatory system GO Biological Processes -47.1670528 52 More
GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO Biological Processes -12.8867024 12 More
GO:0003073 regulation of systemic arterial blood pressure GO Biological Processes -22.2238525 34 More
GO:0006939 smooth muscle contraction GO Biological Processes -6.47455620 13 More
GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO Biological Processes -7.01019683 9 More
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway GO Biological Processes -11.6592522 24 More
GO:0007204 positive regulation of cytosolic calcium ion concentration GO Biological Processes -15.6883547 39 More
GO:0007507 heart development GO Biological Processes -29.3002557 91 More
GO:0007610 behavior GO Biological Processes -18.1916656 76 More
GO:0007611 learning or memory GO Biological Processes -7.55755517 33 More
GO:0008015 blood circulation GO Biological Processes -65.7270163 119 More
GO:0008016 regulation of heart contraction GO Biological Processes -27.6827716 55 More
GO:0008217 regulation of blood pressure GO Biological Processes -35.2019435 60 More
GO:0009612 response to mechanical stimulus GO Biological Processes -18.7627330 44 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0010743 regulation of macrophage derived foam cell differentiation GO Biological Processes -20.3455172 15 More
GO:0010817 regulation of hormone levels GO Biological Processes -29.5190556 49 More
GO:0010942 positive regulation of cell death GO Biological Processes -48.7037743 123 More
GO:0010959 regulation of metal ion transport GO Biological Processes -23.6318171 71 More
GO:0014061 regulation of norepinephrine secretion GO Biological Processes -4.75202065 4 More
GO:0014706 striated muscle tissue development GO Biological Processes -21.0654252 44 More
GO:0014829 vascular associated smooth muscle contraction GO Biological Processes -5.72938190 7 More
GO:0019216 regulation of lipid metabolic process GO Biological Processes -24.8423986 38 More
GO:0019229 regulation of vasoconstriction GO Biological Processes -25.9471687 22 More
GO:0019725 cellular homeostasis GO Biological Processes -21.1508273 85 More
GO:0019932 second-messenger-mediated signaling GO Biological Processes -19.1717114 46 More
GO:0030335 positive regulation of cell migration GO Biological Processes -66.7331035 139 More
GO:0031347 regulation of defense response GO Biological Processes -64.5971043 148 More
GO:0031349 positive regulation of defense response GO Biological Processes -32.1301903 71 More
GO:0031644 regulation of nervous system process GO Biological Processes -8.22607591 24 More
GO:0032103 positive regulation of response to external stimulus GO Biological Processes -58.7273809 118 More
GO:0032368 regulation of lipid transport GO Biological Processes -34.5766289 54 More
GO:0032870 cellular response to hormone stimulus GO Biological Processes -24.7707938 79 More
GO:0032928 regulation of superoxide anion generation GO Biological Processes -6.91942497 9 More
GO:0033674 positive regulation of kinase activity GO Biological Processes -29.8538991 87 More
GO:0034103 regulation of tissue remodeling GO Biological Processes -21.5631413 32 More
GO:0034762 regulation of transmembrane transport GO Biological Processes -31.7284805 100 More
GO:0034764 positive regulation of transmembrane transport GO Biological Processes -18.2616571 46 More
GO:0034765 regulation of ion transmembrane transport GO Biological Processes -18.4305966 71 More
GO:0034767 positive regulation of ion transmembrane transport GO Biological Processes -11.2867591 18 More
GO:0035051 cardiocyte differentiation GO Biological Processes -18.7205561 33 More
GO:0035150 regulation of tube size GO Biological Processes -44.5138102 41 More
GO:0035296 regulation of tube diameter GO Biological Processes -44.6572858 41 More
GO:0040007 growth GO Biological Processes -14.0580178 53 More
GO:0040008 regulation of growth GO Biological Processes -30.7609323 104 More
GO:0040017 positive regulation of locomotion GO Biological Processes -69.9490345 147 More
GO:0042310 vasoconstriction GO Biological Processes -9.70418585 13 More
GO:0042311 vasodilation GO Biological Processes -18.7593927 16 More
GO:0042692 muscle cell differentiation GO Biological Processes -15.1559811 45 More
GO:0043065 positive regulation of apoptotic process GO Biological Processes -46.1285536 112 More
GO:0043068 positive regulation of programmed cell death GO Biological Processes -46.5713594 114 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0043269 regulation of ion transport GO Biological Processes -36.9814668 116 More
GO:0043270 positive regulation of ion transport GO Biological Processes -23.5832054 34 More
GO:0043405 regulation of MAP kinase activity GO Biological Processes -18.9267681 42 More
GO:0043408 regulation of MAPK cascade GO Biological Processes -57.2547066 142 More
GO:0043434 response to peptide hormone GO Biological Processes -26.1739008 69 More
GO:0043549 regulation of kinase activity GO Biological Processes -36.8507249 123 More
GO:0044057 regulation of system process GO Biological Processes -61.6610386 136 More
GO:0044089 positive regulation of cellular component biogenesis GO Biological Processes -10.7794496 56 More
GO:0045428 regulation of nitric oxide biosynthetic process GO Biological Processes -19.2075726 26 More
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO Biological Processes -3.18614571 7 More
GO:0045765 regulation of angiogenesis GO Biological Processes -63.6171248 109 More
GO:0045777 positive regulation of blood pressure GO Biological Processes -5.41560423 6 More
GO:0045859 regulation of protein kinase activity GO Biological Processes -34.3615088 109 More
GO:0045926 negative regulation of growth GO Biological Processes -11.4342361 38 More
GO:0046883 regulation of hormone secretion GO Biological Processes -20.4338227 29 More
GO:0048167 regulation of synaptic plasticity GO Biological Processes -4.27696718 22 More
GO:0048589 developmental growth GO Biological Processes -14.0580178 53 More
GO:0048738 cardiac muscle tissue development GO Biological Processes -21.5979622 44 More
GO:0048771 tissue remodeling GO Biological Processes -15.8777137 28 More
GO:0050433 regulation of catecholamine secretion GO Biological Processes -6.37680507 13 More
GO:0050727 regulation of inflammatory response GO Biological Processes -68.5964592 121 More
GO:0050729 positive regulation of inflammatory response GO Biological Processes -38.1621935 57 More
GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO Biological Processes -27.1120967 60 More
GO:0050804 modulation of chemical synaptic transmission GO Biological Processes -15.2260557 60 More
GO:0050890 cognition GO Biological Processes -8.00500082 37 More
GO:0051046 regulation of secretion GO Biological Processes -54.0079540 130 More
GO:0051047 positive regulation of secretion GO Biological Processes -32.2282376 71 More
GO:0051090 regulation of DNA-binding transcription factor activity GO Biological Processes -25.8933515 78 More
GO:0051091 positive regulation of DNA-binding transcription factor activity GO Biological Processes -17.7436786 49 More
GO:0051146 striated muscle cell differentiation GO Biological Processes -10.9431474 33 More
GO:0051272 positive regulation of cellular component movement GO Biological Processes -66.5150412 143 More
GO:0051345 positive regulation of hydrolase activity GO Biological Processes -19.7369783 79 More
GO:0051347 positive regulation of transferase activity GO Biological Processes -26.6059528 90 More
GO:0051924 regulation of calcium ion transport GO Biological Processes -18.2498286 49 More
GO:0051952 regulation of amine transport GO Biological Processes -10.5179624 22 More
GO:0051954 positive regulation of amine transport GO Biological Processes -5.35296451 10 More
GO:0055001 muscle cell development GO Biological Processes -11.3600709 30 More
GO:0055006 cardiac cell development GO Biological Processes -9.70685856 18 More
GO:0055007 cardiac muscle cell differentiation GO Biological Processes -10.4553674 21 More
GO:0055082 cellular chemical homeostasis GO Biological Processes -17.6289728 71 More
GO:0060537 muscle tissue development GO Biological Processes -18.3336784 54 More
GO:0061061 muscle structure development GO Biological Processes -23.2569142 77 More
GO:0061097 regulation of protein tyrosine kinase activity GO Biological Processes -4.69934335 14 More
GO:0061098 positive regulation of protein tyrosine kinase activity GO Biological Processes -4.90193440 11 More
GO:0071417 cellular response to organonitrogen compound GO Biological Processes -26.3253267 90 More
GO:0071496 cellular response to external stimulus GO Biological Processes -17.0078490 52 More
GO:0071825 protein-lipid complex subunit organization GO Biological Processes -20.9970896 17 More
GO:0071827 plasma lipoprotein particle organization GO Biological Processes -21.6197515 17 More
GO:0071900 regulation of protein serine/threonine kinase activity GO Biological Processes -19.5794055 63 More
GO:0072001 renal system development GO Biological Processes -17.7796243 52 More
GO:0080164 regulation of nitric oxide metabolic process GO Biological Processes -19.7892071 27 More
GO:0090066 regulation of anatomical structure size GO Biological Processes -32.7608623 52 More
GO:0090257 regulation of muscle system process GO Biological Processes -33.9441291 67 More
GO:0090322 regulation of superoxide metabolic process GO Biological Processes -9.31154255 13 More
GO:0097006 regulation of plasma lipoprotein particle levels GO Biological Processes -27.6960426 22 More
GO:0097746 blood vessel diameter maintenance GO Biological Processes -44.6572858 41 More
GO:0099177 regulation of trans-synaptic signaling GO Biological Processes -15.1793607 60 More
GO:1901184 regulation of ERBB signaling pathway GO Biological Processes -3.96203474 12 More
GO:1901186 positive regulation of ERBB signaling pathway GO Biological Processes -3.03839152 7 More
GO:1901342 regulation of vasculature development GO Biological Processes -64.8504074 111 More
GO:1901652 response to peptide GO Biological Processes -34.9047734 89 More
GO:1901653 cellular response to peptide GO Biological Processes -21.5212108 58 More
GO:1901699 cellular response to nitrogen compound GO Biological Processes -26.9091664 96 More
GO:1903522 regulation of blood circulation GO Biological Processes -44.9821911 79 More
GO:1903530 regulation of secretion by cell GO Biological Processes -45.6472055 114 More
GO:1903532 positive regulation of secretion by cell GO Biological Processes -27.9542102 63 More
GO:1904062 regulation of cation transmembrane transport GO Biological Processes -18.6629834 61 More
GO:1904064 positive regulation of cation transmembrane transport GO Biological Processes -10.8655330 17 More
GO:1905952 regulation of lipid localization GO Biological Processes -40.6150331 64 More
GO:2000147 positive regulation of cell motility GO Biological Processes -67.8620360 143 More
GO:2000377 regulation of reactive oxygen species metabolic process GO Biological Processes -19.1025541 38 More
KEGG pathways: 5 records
KEGG Description Category LogP Number of genes Detail
hsa04080 Neuroactive ligand-receptor interaction KEGG Pathway -22.6219922 65 More
hsa04261 Adrenergic signaling in cardiomyocytes KEGG Pathway -3.35554526 8 More
hsa04924 Renin secretion KEGG Pathway -9.25913478 11 More
hsa05200 Pathways in cancer KEGG Pathway -30.6393212 92 More
hsa05414 Dilated cardiomyopathy KEGG Pathway -7.04373804 18 More
Drug-Gene interaction
view
Related drugs: 14 records
Drug name Interaction type Source PMID View
adriamycin NCI 7581027 view
amlodipine PharmGKB view
aspirin PharmGKB 20824505 view
atenolol PharmGKB 1159309814700505 view
benazepril PharmGKB 1726165925143324 view
chlorthalidone PharmGKB view
cyt006-angqb TdgClinicalTrial view
enalapril NCI 11928713 view
hydrocortisone NCI 15576665 view
imidapril PharmGKB 25143324 view
irbesartan PharmGKB 115930981561402614700505 view
lisinopril PharmGKB view
mestranol NCI 3023023 view
quinapril NCIPharmGKB 1269337911849656 view
Related studies: 13 records
Molecular factor Omics type Application Objective MI type Reference
NM_001384479.1:c.593C>T genomics myocardial infarction[diagnosis] myocardial infarction Chistiakov DA et al. Genetika. 1999
NM_001384479.1:c.593C>T genomics ST elevation myocardial infarction[diagnosis] ST elevation myocardial infarction Konopka A et al. Mol Diagn Ther. 2011
NM_001384479.1:c.704T>C genomics myocardial infarction[diagnosis] myocardial infarction Kamitani A et al. Hypertension. 1995
NM_001384479.1:c.704T>C genomics myocardial infarction[diagnosis] myocardial infarction Chen D et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 1998
NM_001384479.1:c.704T>C genomics myocardial infarction[diagnosis] myocardial infarction Fernandez-Arcas N et al. Atherosclerosis. 1999
NM_001384479.1:c.704T>C genomics myocardial infarction[diagnosis] myocardial infarction Olivieri O et al. J Hypertens. 2001
NM_001384479.1:c.704T>C genomics myocardial infarction[diagnosis] myocardial infarction Fernandez-Arcas N et al. Clin Genet. 2001
NM_001384479.1:c.704T>C genomics myocardial infarction[diagnosis] myocardial infarction Schelleman H et al. Eur J Hum Genet. 2007
NM_001384479.1:c.704T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Mehri S et al. J Renin Angiotensin Aldosterone Syst. 2011
NM_001384479.1:c.704T>C genomics left circumflex artery culprit lesion[other] ST elevation myocardial infarction Konopka A et al. Gene. 2012
NM_001384479.1:c.704T>C genomics left ventricular remodeling[prognosis (bad)] acute myocardial infarction Zaliaduonyte-Peksiene D et al. J Renin Angiotensin Aldosterone Syst. 2014
NM_001384479.1:c.704T>C genomics acute myocardial infarction[diagnosis] acute myocardial infarction Raygan F et al. Croat Med J. 2016
NM_001384479.1:c.704T>C genomics acute ST elevation myocardial infarction[diagnosis] acute ST elevation myocardial infarction Isordia-Salas I et al. Blood Coagul Fibrinolysis. 2018
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